Jobim 2008
نویسندگان
چکیده
We propose a modelling strategy to determine from a large set of reactions the smallest set necessary to be compatible with a compendium of required properties and experimental data. We applied this strategy to define a model of hepatic fatty acid metabolism integrating both metabolic pathways and the contribution of some major genetic regulators. We considered the fatty acid metabolism in hepatic cells of mice during a 72 hours fed-to-fast transition and we tested the key role of oxidation and elongation in fatty acid metabolism
منابع مشابه
Natural killer cells and immune surveillance.
OBJECTIVES To analyze the importance of natural killer cells, their killer immunoglobulin-like receptors (KIR) and genes in autoimmunity and in the immune surveillance against infectious agents and stem cells transplantation. The characteristics and polymorphisms of the KIR genes and receptors in the Brazilian population is described. SOURCES Textbooks, review articles and recent scientific a...
متن کاملSimka: large scale de novo comparative metagenomics
Comment citer ce document : Benoit, G. (Auteur de correspondance), Peterlongo, P., Mariadassou, M., Drezen, E., Schbath, S., Lavenier, D., Lemaitre, C. (2017). Simka: large scale de novo comparative metagenomics. In: JOBIM 2017 LILLE (p. 3-5). Presented at JOBIM 2017 Journées Ouvertes Biologie Informatique Mathématiques, Lille, FRA (2017-07-03 2017-07-06). Simka: large scale de novo comparative...
متن کاملJobim 2008
Thermophilic organisms require proteins that maintain their structure and activity in the extreme temperature conditions in which their hosts thrive. In view of evaluating the influence of temperature on the different types of interactions that stabilize protein structures, we developed a new approach based on temperature-dependent mean force potentials. Our results show that the stabilizing we...
متن کاملAutoimmune rheumatic diseases and their association with killer immunoglobulin-like receptor genes.
Killer Immunoglobulin-like Receptor (KIR) genes express as receptors that activate or inhibit Natural Killer (NK) cells. The NK cells are part of the innate immune response and, through their KIR receptors, they identify target cells that have modified or different HLA (Human Leukocyte Antigen) molecules, inducing their lysis. The KIR receptors result from the expression of KIR genes (19q13.14)...
متن کاملCharacteristics of NK cell activity in patients with systemic sclerosis.
INTRODUCTION Previous studies have shown an increased expression of natural killer (NK) cells in the peripheral blood of patients with systemic sclerosis (SSc). NK cells are part of innate immunity, recognizing infected cells through killer immunoglobulin-like receptors (KIR), which show marked polymorphism. A novel model has been proposed predicting the activity of NK cells, evaluating whether...
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